CD57+ EMRA CD8+ T CELLS IN CANCER PATIENTS OVER 70: ASSOCIATIONS WITH PRIOR CHEMOTHERAPY AND RESPONSE TO ANTI-PD-1/PD-L1 THERAPY

CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy

Abstract Background Immune ageing complicates cancer treatment in older individuals.While immunotherapy targeting the PD-1/PD-L1 pathway can reinvigorate T cells, these cells tend to become senescent with age.This study investigates different CD8+ T cell viqua-f4 subsets usually associated with senescence, in cancer patients over 70 years old who a

read more